No, configuration can be done at your desk, with only a USB cable connected to the front USB.
Remember on the AMP-D225H, the amplification circuitry is inactive when you only supply it with USB power.
Open a browser and enter http://192.168.0.4 in the address field.
If it doesn't load the configuration page, check the steps in this article:
Not able to access website via USB on amplifiers and control systems with GUI